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Gabapentin Drug Information

FAQ’s on Gabapentin

Gabapentin FAQ

Neurological disorders are common now days. Epilepsy or neurological pains are worse disease. Gabapentin is a drug which is approved by FDA and showing good pharmacological activity against epilepsy and post herpetic pains. Let have a look about gabapentin, here are some FAQ related to this.

What is Gabapentin?

Gabapentin is an anticonvulsant and analgesic drug. It is mainly used to treat epilepsy, as it controls seizures by decreasing abnormal excitement in the brain. It is likewise employed in pain caused by post herpetic neuralgia. Its mechanism of action is not recognized until now. But it resembles to GABA (gamma amino butyric acid).

What is the chemical structure of gabapentin?

Gabapentin is an analog of GABA (gamma amino butyric acid, it is a neurotransmitter). Its chemical structure consists of the addition of the Cyclo – hexyl group to gamma amino butyric acid (GABA).

Gabapentin Structural Formula

Gabapentin ingredients

Gabapentin is a white to off-white crystalline solid with pka1 of 3.7 and pka2 of 10.7 respectively. It is freely soluble in water and both in acidic and basic solutions. Each gabapentin capsule contains 100 mg, 300 mg, and 400 mg of gabapentin and the following inactive ingredients: gelatine, lactose, titanium dioxide, cornstarch, talc, F&D blue no. 2, yellow iron oxide (400 mg only).

Each gabapentin pill contains 600 mg and 800 mg of gabapentin and the below given inactive ingredients: poloxamer 407, copovidone, corn starch, magnesium stearate, hydroxypropyl cellulose, talc and candelilla wax.

Gabapentin oral solution contains 250 mg of gabapentin per 5 mL (50 mg per mL) and the following inactive ingredients: purified water, xylitol, glycerine and artificial cool strawberry anise flavour.

What is the mechanism of action of gabapentin?

Gabapentin decreases frequency of seizures, as it aids in controlling seizures, which occurs in epilepsy. In animals, gabapentin show tremendous activity in controlling seizures. As its mechanism of action is not recognized, but hypothetically, gabapentin interaction with the high affinity binding site in brain membrane, which has been regulating secondary side of the voltage sensitive Ca+2 channel, equally it can traverse the blood brain barrier and can work on the situation. It is also found out in some study that it can cross the lipid membrane barrier. It increases the synthesis of GABA. It also reduces pain sensation to the brain.

Is gabapentin a drug of abuse? Is gabapentin a narcotic?

No, gabapentin is not an abuse, as its mechanism of action is not related to gamma amino butyric acid (GABA). It does not have an affinity for benzodiazepine, cannabis, or aphids receptor sites. These are the site which is related or responsible for a drug to be addictive. Gabapentin act as neurotransmitters and slow down the activity of the brain. Thus, it also helps in reliving post herpetic pain, by decreasing pain sensation. Is Gabapentin addictive?

Gabapentin Capsules

Is gabapentin a prescription drug?

Yes. Gabapentin is a prescription drug.

What are the brand names for gabapentin drug?

Neurontin, Gralise, Horizant, Fanatrex

What are the different strength of Gabapentin Drugs available?

Gabapentin Oral Capsule: 100MG, 300MG, 400MG

Gabapentin Oral Solution: 250MG/5ML

Gabapentin Oral Tablet: 600MG, 800MG

Precaution taken before Gabapentin

You should not take this medicine, if you are allergic to gabapentin salt. You should tell your doctor, if you have problems related to kidney, liver and heart. You must take this medicine in strict medical supervision as some people have reported mood swings while taking this medication. It comes under schedule C, therefore, cannot be taken in pregnancy because it can harm unborn child.

When to take gabapentin

Gabapentin should be taken after meal as prescribed by the doctor. It should not be taken during day time. For best result, one should take it before going to bed. Do not stop medication suddenly, even if you feel fine because suddenly stopping the medicine can cause increased seizures.

What if you miss a dose?

If you miss a dose, try to take as soon as possible with food and other dose at the same scheduled time. In case of overdose, please call the doctor as soon as possible. You might see some withdrawal symptoms if you stop taking medicine.

What is the common side effect of gabapentin?

There are some common side-effects shown by the gabapentin, which are as follows;

Nausea,
vomiting,
dizziness,
weakness,
tiredness,
blurred vision/ double vision,
hearing impairment,
loss of coordination (shaking of part of the body),
unusual eye movement,
headache,
constipation,
anxiety,
depression,
dry mouth,
joint pain.

What is the rare side-effect of gabapentin?

Some of the side effect is rare and need immediate attention of a doctor, these are as follows:

Rash, cough, persistent sore throat, swelling of mouth, swelling of face, swelling hands and feet, fever, chocking, breathlessness, seizures, yellowing of skin due liver impairment, low blood pressure, allergic reaction, numbness and tingling, multiple organ failure, frequent urination, pneumonia, enlarged lymph nodes hyperactive behaviour, low sodium amount, large purple or brown patches on skin, speaking difficulty, exaggerated deep reflexes, muscle pain, slight sleep, indigestion, pink eye, itching, inflammation of gums and throat, decreased white blood cells, urinary tract infection, muscle damage due kidney failure.

If any of the above symptoms occurs, please contact your physician.

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Every effort has been made to ensure that the information provided by us is accurate, up-to-date and complete, but no guarantee is made to that effect. This drug related disclaimer is not intended to cover all possible uses, direction, precaution, warning, drug interaction, allergic reaction, or adverse effects. The drug information contained herein may be sensitive and should not be utilized as a reference source beyond the date hereof. This material does not endorse drugs, diagnose patient or recommend therapy. The absence of a warning for a given drug or combination thereof in no way should be constructed to indicate the drug is safe, effective or appropriate for any given patient. If you have questions about the drugs you are taking, check your doctor, nurse or pharmacist.

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