is it safe to take gabapentin and diclofenac at the same time
A study was conducted to determine whether gabapentin and diclofenac can be taken together? To evaluate the drug interaction between gabapentin and diclofenac, the study was conducted on formalin induced inflammation. The fixed dose ratio of these drugs was administered orally and locally in peripheral injured paw in rats. Isobolographic analyses were used to define the interaction between the drugs. Theoretically ED30 values were determined from a combination of gabapentin and diclofenac. The values were higher than that of experimental values, which shows that gabapentin and diclofenac can be taken together. As they show synergistic effect without motor impairment side effect, it is a good indication of drug profile.