Ibuprofen and Gabapentin drug interactions
A study was conducted to determine whether gabapentin and ibuprofen can be taken together? Ibuprofen and gabapentin combination was administered locally in the formalin injured paw and the anti-inflammatory effect was evaluated using 5% formalin test. ED30 value was determined, the result values were significantly doubled than individual drug. These results correspond the synergistic interaction between ibuprofen and gabapentin at a peripheral level, potency being three times higher with regards to that expected from the addition of the effect of the individual drug. Ibuprofen and gabapentin interact synergistically therefore drug association may represent a therapeutic advantage in the clinical treatment of inflammatory pain.