Gabapentin and wellbutrin drug interactions

When gabapentin is taken with wellbutrin, no interaction occurred between them. But, these drugs can be used for smoking cessation. A six week, randomized, open label pilot study estimated the treatment effect of gabapentin compared with wellbutrin for smoking cessation. The study was divided into two parts, primary outcome measured smoking cessation and secondary outcome measured smoking reduction and withdrawal severity. Gabapentin was less efficacious than wellbutrin for smoking cessation, but was associated with fewer dropouts from adverse effects. Withdrawal severity was found out to be less with wellbutrin. Therefore, wellbutrin remains first line nonnicotin pharmacotherapy for smoking cessation. Further study is required to determine gabapentin effect on smoking cessation.

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