Gabapentin use while Breastfeeding
Gabapentin is an older anticonvulsant used primarily for partial seizures with or without secondary generalization. In a study of five mother infant pairs receiving 900-3200 mg gabapentin per day, the mean milk/ plasma ratio ranged from 0.7 to 1.2 from two weeks to three months postpartum. At 2-3 weeks, two out of five infants had detectable concentration of gabapentin (1.3 & 1.5) and one infant was undetectable. These levels were far below the normal plasma levels in the mothers (11-45). Assuming a daily milk intake of 150/mL/day/kg, the infant dose of gabapentin was estimated to be 0.2-1.3 mL/day/kg, which is equivalent to 1.3-3.8 % of the weight normalized dose received by the mother. The plasma levels of gabapentin collected after 3 months of breastfeeding in another infant were 1.9. Thus, result from the study concluded that the plasma levels were low and no adverse effects were reported in the infants.